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the volume determines the concentration of the working solution Concentration control: because the volume of the solvent is determined by the researcher, the concentration of the working solution is fully under his control – the product does not impose doses or concentrations Protein reconstitution: the solvent is not introduced directly onto the lyophilisate cake, but in a slow stream along the wall of the vial

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doi: 10.1016/j.ijpharm.2021.121030